Loxton Knight was born in Long Eaton, Derbyshire where he studied at the local grammer school before entering Nottingham School of Art (1924-9). He exhibited extensively at the Royal Society of British Artists, Royal Institute of Painters in Water Colours, New Group and elsewhere. He held solo exhibitions at the Brooks Street Gallery, Chapel Bar Gallery in Nottingham and Carl Fischer Gallery in New York. A memorial exhibition was held at Erewash Museum, Derbyshire in 1994.
Works by him are in many public collections in Britain and abroad. His art was very widely seen since his true genius lay in poster design and advertising art. When still a student he produced what is probably his best known image, the striking and somewhat sinister silhouette figure for Sandeman Port. He was also one of that select group of artists whose work belongs to the golden age of the British Railway Poster.